Bacterial Collagenase

Corynebacterium rathayil bacterial collagenase

Athanasios YIOTAKIS,* Alain LECOQ,t Anna NICOLAOU,* Jean LABADIEt and Vincent DIVEt§ TDepartment of Organic Chemistry, Laboratory of Organic Chemistry, University of Athens, Panepistimiopolis, Zografou, Athens 15771, Greece, tDepartement d'lng6nierie et d'Etudes des Prot6ines, D.S.V., C.E.A. CE-Saclay, 91191 Gif/Yvette, Cedex, France, and tStation de Recherches sur la Viande, INRA de Theix, 631...

Inhibitors of Bacterial Collagenase

Procollagen propeptide release by procollagen peptidases and bacterial collagenase.

Amino and carboxyl procollagen peptidases cleaved chick procollagen I to yield the intact amino propeptides and the disulfide-linked carboxyl propeptides, which were identified and partly characterized. The same products were released by these enzymes from the two separated fragments of procollagen produced by vertebrate collagenase, and this supports the concept that cleavage of amino and carb...

Interactions of tervalent lanthanide ions with bacterial collagenase (clostridiopeptidase A).

Tervalent cations of the lanthanide (rare-earth) elements reversibly inhibit bacterial collagenase (clostridiopeptidase A; EC 3.4.24.3). Sm(3+), whose ionic radius is closest to that of Ca(2+), is the most effective inhibitor, completely suppressing clostridiopeptidase activity at a concentration of 100mum in the presence of 5mm-Ca(2+). Er(3+) and Lu(3+), which both have ionic radii smaller tha...

Keratoconus experimentally produced in mice using collagenase

Introduction: Keratoconus is a relatively common disease of cornea in which structural changes within the cornea cause it to thin and change to a conical shape and scar at the central portion of cornea. So far, few methods and drug treatments were introduced due to both lack of accepted animal models to induce experimental keratoconus and limitation of research in human considering ethical issu...